1. Supports a healthy skin microbiome: Postbiotics help maintain a balanced skin
   microbiome, which may play a role in supporting overall skin health.
2. Promotes hydration: Postbiotics can help improve skin moisturization, elasticity, and
   the appearance of fine lines and pores.
3. Helps manage skin irritation: Postbiotics may help soothe irritation and support the
   skin’s natural healing processes, which can be beneficial for skin conditions like acne.
4. Provides antioxidant support: Postbiotics may help protect the skin from
   environmental stressors, such as free radicals and UV damage, which can contribute to
   the appearance of aging.

Together, postbiotics can help support overall skin health, contributing to a resilient and smooth
skin.

Introduction

Our skin is not only aDected by what we put on it, but also by what’s happening inside our bodies,
particularly in our gut. This connection between gut health and skin appearance is known as the
gut-skin axis​¹. Emerging research has shown that a healthy gut microbiome can have a positive
impact on our skin. Our microbiome consists of beneficial bacteria, named probiotics. These
probiotics can produce so-called postbiotics: beneficial compounds that are known for their
health eDects. Postbiotics have been found to provide a range of benefits for the skin, making
them an important part of a skincare routine that works from the inside out. YIXIY is a vitality
product which contains both natural post- and probiotics. In this blog, we will explore four
benefits of postbiotics for our skin!

1. Balancing the skin microbiome

Did you know that the skin is the largest organ of our body and that it even has its own
microbiome? Skin microbiota contains over 800 diverse types of microbes². A single square
centimetre of the human skin can contain up to one billion microorganisms³. Postbiotics can
promote the growth of beneficial bacteria while inhibiting harmful ones, maintaining a balanced
skin microbiome^4,5. This balance is crucial for preventing skin infections and maintaining overall
skin health. Disbalance of the skin microbiome, known as dysbiosis, has been associated with
several skin conditions such as eczema and psoriasis⁶. By supporting a healthy, balanced
microbiome, postbiotics contribute to a resilient and healthy skin microbiome.

2. Boosting skin hydration

Postbiotics can be a game-changer for skin hydration. Healthy skin hydration is essential for
maintaining a smooth and youthful appearance, as well as protecting against irritation. Studies
have shown that postbiotics from S. Thermophilus, L. casei, and L. Rhamnosus can help increase
skin moisturization ^7,8 and promote better elasticity⁷. These postbiotics have also been linked to
reducing the appearance of wrinkles and minimizing pore size⁷. Additionally, postbiotics from B.
Longum are known to strengthen the skin barrier, while also decreasing skin sensitivity and
roughness ⁹. Notably, higher concentrations of propionate, another postbiotic, have been found in
people with well-hydrated skin, suggesting that maintaining propionate levels could support a
moisturized, healthy skin. Overall, postbiotics play a relevant role in supporting skin hydration,
contributing to a healthy appearance.

3. Calming the skin: Reducing inflammation and aiding wound recovery

Skin conditions like eczema, acne, and psoriasis often come with inflammation, which can cause
redness, irritation, and discomfort. Postbiotics can help manage inflammation in the body^10-15,
soothing irritated skin. For example, postbiotics from L. rhamnosus have been shown to decrease
redness of the skin⁸. Additionally, postbiotics like peptidoglycans and exopolysaccharides play a
role in supporting wound healing⁴, helping the skin recover and stay healthy. In the case of acne,
postbiotics like pyruvic acid, a specific postbiotic, has been shown to reduce skin greasiness
through peelings¹⁶. By targeting both inflammation and skin healing, postbiotics provide a natural
solution to boost your skin’s health.

4. Antioxidant protection: Shielding skin from damage and aging

Our skin is constantly exposed to environmental toxins, UV rays, and free radicals that can break
down collagen, a key protein that keeps our skin firm and elastic. Reductions in collagen can lead
to signs of aging like wrinkles and rough skin texture. Luckily, some postbiotics support powerful
antioxidant protection, helping to shield the skin from this damage¹⁷. Postbiotics from the
fermentation by lactic acid bacteria in kimchi have been shown to block enzymes that break down
collagen¹⁸, helping to keep the skin firm and youthful. Another postbiotic named glycolic acid
boosts collagen production, helping repair skin damaged by the sun¹⁹. It also improves skin
texture and reduces signs of hyperpigmentation¹⁸ and aging, such as wrinkles and roughness¹⁸.
Additionally, glycolic acid has been reported to help with acne²¹. Moreover, application of butyric
acid, yet another postbiotic, to the skin reduced inflammation caused by UV radiation²². Together,
these postbiotics help protect and rejuvenate the skin.

Summary

Postbiotics oDer several potential benefits for skin health by supporting the skin barrier, reducing
inflammation, and providing antioxidant protection. These postbiotics can help promote a
balanced skin microbiome, which is important for overall skin health. By helping to maintain skin
hydration, soothing irritation, and protecting the skin from environmental stressors, postbiotics
can contribute to a healthier, more resilient skin. Incorporating postbiotics into your skincare
routine may enhance your skin’s natural defenses and overall appearance, nourishing your skin
from within.

The claims made in this article have not been evaluated by the Food and Drug
Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent
any disease.

Figure 1 Effects of probiotics on the skin either by oral consumption or topical application. Source: Rawal, S., & Ali, S. A. (2023). Probiotics and postbiotics play a role in maintaining dermal health. Food & Function, 14(9), 3966-3981. Note: License permission is pending, please do not copy or distribute this image

References

1. Pessemier, B. De, Grine, L., Debaere, M., Maes, A., Paetzold, B., and Callewaert, C. (2021). Gut– Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions. Microorganisms 9, 353. https://doi.org/10.3390/MICROORGANISMS9020353.

​2. Timm, C.M., Loomis, K., Stone, W., Mehoke, T., Brensinger, B., Pellicore, M., Staniczenko, P.P.A.,
Charles, C., Nayak, S., and Karig, D.K. (2020). Isolation and characterization of diverse microbial
representatives from the human skin microbiome. Microbiome 8. https://doi.org/10.1186/S40168-
020-00831-Y.

​3. Cooper, A.J., Weyrich, L.S., Dixit, S., and Farrer, A.G. (2015). The skin microbiome: Associations
between altered microbial communities and disease. Australasian Journal of Dermatology 56,
268–274. https://doi.org/10.1111/AJD.12253.

​4. Rawal, S., and Ali, S.A. (2023). Probiotics and postbiotics play a role in maintaining dermal health.
Food Funct 14, 3966–3981. https://doi.org/10.1039/D3FO00152K.

​5. De Almeida, C.V., Antiga, E., and Lulli, M. (2023). Oral and Topical Probiotics and Postbiotics in Skincare and Dermatological Therapy: A Concise Review. Microorganisms 2023, Vol. 11, Page 1420 11, 1420. https://doi.org/10.3390/MICROORGANISMS11061420. 

​6. Lee, H.J., and Kim, M. (2022). Skin Barrier Function and the Microbiome. International Journal of Molecular Sciences 2022, Vol. 23, Page 13071 23, 13071. https://doi.org/10.3390/IJMS232113071.

​7. Catic, T., Pehlivanovic, B., Pljakic, N., and Balicevac, A. (2022). The Moisturizing Ecicacy of a Proprietary Dermo-Cosmetic Product( CLS02021) Versus Placebo in a 4-week Application Period. https://doi.org/10.5455/medarh.2022.76.108-114. 

​8. Cui, H., Feng, C., Zhang, T., Martínez-Ríos, V., Martorell, P., Tortajada, M., Cheng, S., Cheng, S., and Duan, Z. (123AD). Ecects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study. Scientific Reports | 13, 16879. https://doi.org/10.1038/s41598-023-43336-y. 

​9. Guéniche, A., Bastien, P., Ovigne, J.M., Kermici, M., Courchay, G., Chevalier, V., Breton, L., and Castiel-Higounenc, I. (2010). Bifidobacterium longum lysate, a new ingredient for reactive skin. Exp Dermatol 19, e1–e8. https://doi.org/10.1111/J.1600-0625.2009.00932.X.

10. He, J., Zhang, P., Shen, L., Niu, L., Tan, Y., Chen, L., Zhao, Y., Bai, L., Hao, X., Li, X., et al. (2020). Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism. Int J Mol Sci 21, 1–16. https://doi.org/10.3390/IJMS21176356.

11. Acevedo-Román, A., Pagán-Zayas, N., Velázquez-Rivera, L.I., Torres-Ventura, A.C., and GodoyVitorino, F. (2024). Insights into Gut Dysbiosis: Inflammatory Diseases, Obesity, and Restoration
Approaches. International Journal of Molecular Sciences 2024, Vol. 25, Page 9715 25, 9715.
https://doi.org/10.3390/IJMS25179715.

12. Rocha-Ramírez, L.M., Pérez-Solano, R.A., Castañón-Alonso, S.L., Moreno Guerrero, S.S., Ramírez
Pacheco, A., García Garibay, M., and Eslava, C. (2017). Probiotic Lactobacillus Strains Stimulate
the Inflammatory Response and Activate Human Macrophages. J Immunol Res 2017.
https://doi.org/10.1155/2017/4607491.

13. Baglama, Š.Š., and Trčko, K. (2022). Skin and gut microbiota dysbiosis in autoimmune and
inflammatory skin diseases. Acta Dermatovenerol Alp Pannonica Adriat 31, 105–109.
https://doi.org/10.15570/ACTAAPA.2022.16.

14. Siddiqui, M.T., and Cresci, G.A.M. (2021). The Immunomodulatory Functions of Butyrate. J Inflamm
Res 14, 6025–6041. https://doi.org/10.2147/JIR.S300989.

15. Meijer, K., De Vos, P., and Priebe, M.G. (2010). Butyrate and other short-chain fatty acids as
modulators of immunity: What relevance for health? Curr Opin Clin Nutr Metab Care 13, 715–721.
https://doi.org/10.1097/MCO.0B013E32833EEBE5.

16. Chilicka, K., Rogowska, A.M., Szyguła, R., Dzieńdziora-Urbińska, I., and Taradaj, J. (2020). A comparison of the ecectiveness of azelaic and pyruvic acid peels in the treatment of female adult acne: a randomized controlled trial. Scientific Reports 2020 10:1 10, 1–8. https://doi.org/10.1038/s41598-020-69530-w.

17. Duarte, M., Carvalho, M.J., de Carvalho, N.M., Azevedo-Silva, J., Mendes, A., Ribeiro, I.P., Fernandes, J.C., Oliveira, A.L.S., Oliveira, C., Pintado, M., et al. (2023). Skincare potential of a sustainable postbiotic extract produced through sugarcane straw fermentation by Saccharomyces cerevisiae. BioFactors 49, 1038–1060. https://doi.org/10.1002/BIOF.1975.

18. Lee, Y.S., Lee, S.J., Jang, W.J., and Lee, E.W. (2024). Protective Ecects of the Postbiotic
Levilactobacillus brevis BK3 against H2O2-Induced Oxidative Damage in Skin Cells. J. Microbiol. Biotechnol. 34, 1401–1409. https://doi.org/10.4014/JMB.2403.03010.

19. Bahar Houshmand, E., and Elizabeth Bahar Houshmand, C. (2021). Ecect of glycolic acid, phytic acid, soothing complex containing Emulsion on Hyperpigmentation and skin luminosity: A clinical evaluation. J Cosmet Dermatol 20, 776–780. https://doi.org/10.1111/JOCD.13950.

20. DiNardo, J.C., Grove, G.L., and Moy, L.S. (1996). Clinical and histological ecects of glycolic acid at dicerent concentrations and pH levels. Dermatologic Surgery 22, 421–424. https://doi.org/10.1111/J.1524-4725.1996.TB00341.X.

21. Wang, C.M., Huang, C.L.I., Sindy Hu, C.T., and Chan, H.L. (1997). The ecect of glycolic acid on the treatment of acne in Asian skin. Dermatologic Surgery 23, 23–29. https://doi.org/10.1111/J.15244725.1997.TB00003.X.

22. Keshari, S., Balasubramaniam, A., Myagmardoloonjin, B., Herr, D.R., Negari, I.P., and Huang, C.M.(2019). Butyric Acid from Probiotic Staphylococcus epidermidis in the Skin Microbiome DownRegulates the Ultraviolet-Induced Pro-Inflammatory IL-6 Cytokine via Short-Chain Fatty Acid Receptor. International Journal of Molecular Sciences 2019, Vol. 20, Page 4477 20, 4477. https://doi.org/10.3390/IJMS20184477.

The post Postbiotics: Nourish the skin from within appeared first on YIXIY.

1. Probiotics and Postbiotics for Weight Management: Probiotics and postbiotics both play a role in managing weight by regulating fat storage 
2. SCFAs and Fat Storage: Short-chain fatty acids (SCFAs), a type of postbiotic, help your body burn fat for energy rather than storing it, while also reducing fat production and boosting fat breakdown, promoting overall weight management 
3. Probiotics Support Gut Health: Beneficial bacteria like Lactobacillus acidophilus and Bifidobacterium longum help balance the gut microbiome, reducing harmful bacteria linked to obesity and preventing excess fat accumulation
4. Appetite Regulation: SCFAs regulate appetite by influencing hormones like leptin and GLP-1, helping you feel fuller and reducing cravings for better eating habits 
5. Metabolism Boost: SCFAs enhance metabolism by fueling energy production and regulating the breakdown of fat and sugar, supporting overall energy balance and metabolic health 

Introduction

You have likely heard that probiotics and postbiotics are important for gut health, but did you know they also play a significant role in managing weight? In this blog, we will dive into how these helpful bacteria and postbiotics throw their weight around when it comes to keeping your body in balance!

Fat storage & probiotic protection

Postbiotics, especially short-chain fatty acids (SCFAs), have a remarkable ability to influence how your body handles fat​¹​. SCFAs can help shift your body’s focus from storing fat to burning it for energy. They work by signaling the liver and fat cells to use fat as fuel rather than storing it, which can ultimately reduce overall fat storage and support weight loss.  

But that is not all. SCFAs also help curb fat production in your body. They lower the activity of certain genes responsible for fat creation and simultaneously increase the activity of genes that break down and burn fat ​^2,3​. In essence, SCFAs support your body in getting rid of excess fat, rather than contributing to new fat buildup. 

Additionally, probiotics, like Lactobacillus acidophilus, Bifidobacterium longum, and Lactobacillus plantarum, further support weight management by promoting a healthier gut microbiome. These beneficial bacteria help reduce harmful bacteria linked to obesity while increasing beneficial bacteria that aid in digestion and metabolism. Research shows that probiotics can counteract weight gain caused by high-fat, high-sugar diets by restoring the balance of good bacteria in the gut, which can help preventing excess fat accumulation​⁴​.  

Moreover, in a meta-analysis that reviewed 200 trials with over 12,600 participants​⁶​, it was found that taking probiotics led to significant improvements in weight and body composition​^6,8​.  

Appetite regulation 

In addition to influencing fat storage, SCFAs also play a role in regulating appetite ​^2,3​. They impact key hormones involved in hunger and metabolism, such as leptin and GLP-1. Leptin helps you feel full, reducing the desire to overeat, while GLP-1 not only helps regulate blood sugar but also plays a role in reducing appetite. By promoting the production of these hormones, SCFAs can support more controlled eating habits and contribute to weight management. 

Metabolism 

SCFAs, particularly acetate, propionate, and butyrate, play a valuable role in regulating your body’s energy balance​^5,7,9​. These fatty acids serve as a source of fuel for energy production, influencing processes like fat creation, sugar production, and the breakdown of sugars. In doing so, they help regulate how your body uses and stores energy, making them key players in maintaining a healthy metabolism. 

Summary

Probiotics and postbiotics offer a powerful one-two punch when it comes to managing weight. They not only help regulate fat storage and metabolism but also support appetite control and improve gut health. By balancing the bacteria in your gut, these beneficial compounds help your body function at its best, leading to better energy regulation and healthier weight management. So, let’s thank the powerful pro- & postbiotics for taking this weight off our shoulders! 

References

1.            Den Besten, G., Bleeker, A., Gerding, A., Van Eunen, K., Havinga, R., Van Dijk, T.H., Oosterveer, M.H., Jonker, J.W., Groen, A.K., Reijngoud, D.J., et al. (2015). Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation. Diabetes 64, 2398–2408. https://doi.org/10.2337/DB14-1213. 

​2. Jiao, A., Yu, B., He, J., Yu, J., Zheng, P., Luo, Y., Luo, J., Mao, X., and Chen, D. (2020). Short chain fatty acids could prevent fat deposition in pigs via regulating related hormones and genes. Food Funct 11, 1845–1855. https://doi.org/10.1039/C9FO02585E. 

​3. Jiao, A.R., Diao, H., Yu, B., He, J., Yu, J., Zheng, P., Huang, Z.Q., Luo, Y.H., Luo, J.Q., Mao, X.B., et al. (2018). Oral administration of short chain fatty acids could attenuate fat deposition of pigs. PLoS One 13. https://doi.org/10.1371/JOURNAL.PONE.0196867. 

​4. Kong, C., Gao, R., Yan, X., Huang, L., and Qin, H. (2019). Probiotics improve gut microbiota dysbiosis in obese mice fed a high-fat or high-sucrose diet. Nutrition 60, 175–184. https://doi.org/10.1016/J.NUT.2018.10.002. 

​5. He, J., Zhang, P., Shen, L., Niu, L., Tan, Y., Chen, L., Zhao, Y., Bai, L., Hao, X., Li, X., et al. (2020). Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism. Int J Mol Sci 21, 1–16. https://doi.org/10.3390/IJMS21176356. 

​6. Saadati, S., Naseri, K., Asbaghi, O., Yousefi, M., Golalipour, E., and de Courten, B. (2023). Beneficial effects of the probiotics and synbiotics supplementation on anthropometric indices and body composition in adults: A systematic review and meta‐analysis. Obesity Reviews 25. https://doi.org/10.1111/OBR.13667. 

​7. Schönfeld, P., and Wojtczak, L. (2016). Short- and medium-chain fatty acids in energy metabolism: the cellular perspective. J Lipid Res 57, 943–954. https://doi.org/10.1194/JLR.R067629. 

​8. Borgeraas, H., Johnson, L.K., Skattebu, J., Hertel, J.K., and Hjelmesæth, J. (2018). Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials. Obesity Reviews 19, 219–232. https://doi.org/10.1111/OBR.12626. 

​9. Hu, J., Lin, S., Zheng, B., and Cheung, P.C.K. (2018). Short-chain fatty acids in control of energy metabolism. Crit Rev Food Sci Nutr 58, 1243–1249. https://doi.org/10.1080/10408398.2016.1245650. 

The post Heavyweight helpers “The role of pro- and postbiotics in weight management” appeared first on YIXIY.

Summary

Healthy intestines are essential for a strong immune system and overall well-being.

Postbiotics: YIXIY contains measurable postbiotics. Postbiotics are bioactive compounds produced by probiotics. They provide health benefits such as strengthening the intestinal barrier, improving gut health, and reducing inflammation. Although postbiotics have a broad range of positive effects, some examples are listed below:

• Butyric acid: Nourishes colon cells and helps reduce inflammation.
• Lactic acid: Lowers the pH in the intestines and inhibits harmful microorganisms.
• Acetic acid: Supports weight management and provides energy to body cells.
• Propionic acid: Helps regulate fat storage and supports liver function.
• Succinic acid: May contribute to reducing menopausal symptoms.

A unique feature of postbiotics is that they retain their functionality even when the bacteria producing them are no longer active.

Probiotics: YIXIY contains eight probiotic strains. Below are some specific benefits highlighted for each strain:

• Bifidobacterium lactis: Strengthens the immune system.
• Bifidobacterium longum: Breaks down fibers and reduces inflammation.
• Lactobacillus acidophilus: Improves lactose digestion and promotes calcium absorption.
• Lactobacillus casei: Relieves digestive complaints.
• Lactobacillus rhamnosus: Restores gut flora after antibiotic use.
• Lactobacillus salivarius: Supports oral health.
• Lactococcus lactis: Produces antibacterial substances.
• Streptococcus thermophilus: Aids in lactose digestion.

The postbiotics and probiotics in YIXIY products work together not only to support digestion and the immune system but also to strengthen the integrity of the intestinal barrier. A healthy intestinal barrier is the foundation for optimal nutrient absorption and protection against harmful substances, essential for overall well-being.

Postbiotics

YIXIY contains measurable postbiotics, the most important are: Butyric acid, Lactic acid, Acetic acid, Propionic acid, and Succinic acid.

Postbiotics are the byproducts or substances produced by probiotics during fermentation. This includes a wide range of substances, such as short-chain fatty acids (like butyric acid), peptides, proteins, enzymes, and other metabolites¹⁸. These substances can offer health benefits without the probiotic bacteria themselves needing to be alive. Components of dead probiotic strains, such as cell walls, DNA, and other intracellular components, also fall under postbiotics ¹⁸. When probiotic bacteria die or break down, these components can still influence gut health and the immune system.

Butyric acid

Butyric acid is converted into butyrate in the colon. Butyrate is the primary energy source for the cells of the large intestine (colonocytes)²¹. It promotes the integrity of the gut barrier and can have a protective effect against intestinal inflammation ²².

Lactic acid

Lactic acid lowers the pH in the intestines, which can inhibit the growth of harmful microorganisms ²⁵.

Acetic acid

Acetic acid is quickly absorbed and can serve as an energy source for body cells outside the gut, such as muscle cells. It is also linked to weight management through a reduction in body weight and body fat ^19,20.

Propionic acid

Propionic acid plays a role in fat metabolism and helps reduce fat storage ²³. It can also support liver function and is involved in reducing fat storage in the body, which affects weight management ²³.

Succinic acid

Succinic acid is converted into succinate in the body. A succinate-rich diet is linked to a reduction in menopausal symptoms ²⁴.

Probiotics

YIXIY contains 8 different strains of bacteria: Bifidobacterium lactis, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus salivarius, Lactococcus lactis and Streptococcus thermophilus.

These bacteria are so-called probiotics, which are beneficial microorganisms that support health. They share several common functions. For instance, they help maintain a healthy gut microbiome by inhibiting the growth of harmful bacteria, support digestion by breaking down sugars and fibers, and contribute to the immune system. Additionally, these bacteria produce lactic acid, which lowers the pH in the intestines, helping to limit the growth of harmful microorganisms. Overall, these probiotics promote gut health and support the absorption of essential nutrients.

Bifidobacterium lactis

Bifidobacterium lactis can support the natural immune response ¹.

Bifidobacterium longum

Bifidobacterium longum is specialized in breaking down complex carbohydrates and fibers ². This strain can contribute to a healthy gut flora by reducing inflammation ³.

Lactobacillus acidophilus

Lactobacillus acidophilus plays an important role in the digestion of dairy, especially by converting lactose into lactic acid. This bacterial strain is often associated with reducing symptoms of lactose intolerance⁴. Furthermore, it promotes the absorption of calcium and other minerals ⁵, which is essential for bone health.

Lactobacillus casei

Lactobacillus casei is often associated with relieving digestive complaints⁶. It helps improve the digestion of sugars⁷.

Lactobacillus rhamnosus

Lactobacillus rhamnosus is described for its role in reducing diarrhea following antibiotic use ⁸ or hospital admission ⁹. It can also help restore balance after vaginal dysbiosis ¹⁰.

Lactobacillus salivarius

Lactobacillus salivarius has antimicrobial properties that can contribute to good oral health ¹¹. This strain is linked to reducing gum bleeding and may help with bad breath ^11,12.

Lactococcus lactis

Lactococcus lactis is able to produce nisin¹³. Nisin is a natural antibacterial peptide known for inhibiting the growth of harmful bacteria. Postbiotics from Lactococcus lactis have been linked to skin improvement¹⁴  .

Streptococcus thermophilus

Streptococcus thermophilus helps in the digestion of lactose from dairy products by producing lactase^15,16. Additionally, Streptococcus thermophilus produces various B vitamins, such as folate (B9)¹⁷.

References

1.           Arunachalam, K., Gill, H.S., and Chandra, R.K. (2000). Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019). European Journal of Clinical Nutrition 2000 54:3 54, 263–267. https://doi.org/10.1038/sj.ejcn.1600938.

2.            Pokusaeva, K., Fitzgerald, G., nutrition, D. van S.-G.&, and 2011, undefined (2011). Carbohydrate metabolism in Bifidobacteria. Springer 6, 285–306. https://doi.org/10.1007/s12263-010-0206-6.

3.            Saez-Lara, M.J., Gomez-Llorente, C., Plaza-Diaz, J., and Gil, A. (2015). The Role of Probiotic Lactic Acid Bacteria and Bifidobacteria in the Prevention and Treatment of Inflammatory Bowel Disease and Other Related Diseases: A Systematic Review of Randomized Human Clinical Trials. Biomed Res Int 2015, 505878. https://doi.org/10.1155/2015/505878.

4.            Pakdaman, M.N., Udani, J.K., Molina, J.P., and Shahani, M. (2016). The effects of the DDS-1 strain of lactobacillus on symptomatic relief for lactose intolerance – A randomized, double-blind, placebo-controlled, crossover clinical trial. Nutr J 15, 1–11. https://doi.org/10.1186/S12937-016-0172-Y/FIGURES/1.

5.            Dubey, M.R., and Patel, V.P. (2018). The Open Nutrition Journal Probiotics: A Promising Tool for Calcium Absorption. 12, 59–69. https://doi.org/10.2174/1874288201812010059.

6.            Preston, K., Krumian, R., Hattner, J., Demontigny, D., Stewart, M., and Gaddam, S. (2018). Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study. https://doi.org/10.3920/BM2017.0105 9, 697–706. https://doi.org/10.3920/BM2017.0105.

7.            Viana, R., Monedero, V., Dossonnet, V., Vadeboncoeur, C., Pérez-Martínez, G., and Deutscher, J. (2000). Enzyme I and HPr from Lactobacillus casei: their role in sugar transport, carbon catabolite repression and inducer exclusion. Mol Microbiol 36, 570–584. https://doi.org/10.1046/J.1365-2958.2000.01862.X.

8.            Li, Y.T., Xu, H., Ye, J.Z., Wu, W.R., Shi, D., Fang, D.Q., Liu, Y., and Li, L.J. (2019). Efficacy of Lactobacillus rhamnosus GG in treatment of acute pediatric diarrhea: A systematic review with meta-analysis. World J Gastroenterol 25, 4999. https://doi.org/10.3748/WJG.V25.I33.4999.

9.            Szajewska, H., Wanke, M., and Patro, B. (2011). Meta-analysis: the effects of Lactobacillus rhamnosus GG supplementation for the prevention of healthcare-associated diarrhoea in children. Aliment Pharmacol Ther 34, 1079–1087. https://doi.org/10.1111/J.1365-2036.2011.04837.X.

10.         Pino, A., Rapisarda, A.M.C., Vitale, S.G., Cianci, S., Caggia, C., Randazzo, C.L., and Cianci, A. (2021). A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis. Scientific Reports 2021 11:1 11, 1–12. https://doi.org/10.1038/s41598-021-81931-z.

11.         Iwamoto, T., Suzuki, N., Tanabe, K., Takeshita, T., and Hirofuji, T. (2010). Effects of probiotic Lactobacillus salivarius WB21 on halitosis and oral health: an open-label pilot trial. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 110, 201–208. https://doi.org/10.1016/J.TRIPLEO.2010.03.032.

12.         Suzuki, N., Yoneda, M., Tanabe, K., Fujimoto, A., Iha, K., Seno, K., Yamada, K., Iwamoto, T., Masuo, Y., and Hirofuji, T. (2014). Lactobacillus salivarius WB21–containing tablets for the treatment of oral malodor: a double-blind, randomized, placebo-controlled crossover trial. Oral Surg Oral Med Oral Pathol Oral Radiol 117, 462–470. https://doi.org/10.1016/J.OOOO.2013.12.400.

13.         Liu, W., and Hansen, J.N. (1990). Some chemical and physical properties of nisin, a small-protein antibiotic produced by Lactococcus lactis. Appl Environ Microbiol 56, 2551–2558. https://doi.org/10.1128/AEM.56.8.2551-2558.1990.

14.         Kimoto-Nira, H., Aoki, R., Sasaki, K., Suzuki, C., and Mizumachi, K. (2012). Oral intake of heat-killed cells of Lactococcus lactis strain H61 promotes skin health in women. J Nutr Sci 1, e18. https://doi.org/10.1017/JNS.2012.22.

15.         Huang, Y.Y., Lu, Y.H., Liu, X.T., Wu, W.T., Li, W.Q., Lai, S.Q., Aadil, R.M., Riaz Rajoka, M.S., Wang, L.H., and Zeng, X.A. (2024). Metabolic Properties, Functional Characteristics, and Practical Application of Streptococcus thermophilus. Food Reviews International 40, 792–813. https://doi.org/10.1080/87559129.2023.2202406.

16.         Sharma, R., Bhaskar, B., Sanodiya, B.S., Thakur, G.S., Jaiswal, P., Yadav, N., Sharma, A., and Bisen, P.S. (2014). Probiotic Efficacy and Potential of Streptococcus thermophilus modulating human health: A synoptic review. IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS 9, 52–58.

17.         Iyer, R., Tomar, S.K., Kapila, S., Mani, J., and Singh, R. (2010). Probiotic properties of folate producing Streptococcus thermophilus strains. Food Research International 43, 103–110. https://doi.org/10.1016/J.FOODRES.2009.09.011.

18.         Salminen, S., Collado, M.C., Endo, A., Hill, C., Lebeer, S., Quigley, E.M.M., Sanders, M.E., Shamir, R., Swann, J.R., Szajewska, H., et al. (2021). The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nature Reviews Gastroenterology & Hepatology 2021 18:9 18, 649–667. https://doi.org/10.1038/s41575-021-00440-6.

19.         Cobb, K.M., Chavez, D.A., Kenyon, J.D., Hutelin, Z., and Webster, M.J. (2021). Acetic Acid Supplementation: Effect on Resting and Exercise Energy Expenditure and Substrate Utilization. Int J Exerc Sci 14, 222.

20.         Kondo, T., Kishi, M., Fushimi, T., and Kaga, T. (2009). Acetic acid upregulates the expression of genes for fatty acid oxidation enzymes in liver to suppress body fat accumulation. J Agric Food Chem 57, 5982–5986. https://doi.org/10.1021/JF900470C/ASSET/IMAGES/LARGE/JF-2009-00470C_0002.JPEG.

21.         Pryde, S.E., Duncan, S.H., Hold, G.L., Stewart, C.S., and Flint, H.J. (2002). The microbiology of butyrate formation in the human colon. FEMS Microbiol Lett 217, 133–139. https://doi.org/10.1111/J.1574-6968.2002.TB11467.X.

22.         Siddiqui, M.T., and Cresci, G.A.M. (2021). The Immunomodulatory Functions of Butyrate. J Inflamm Res 14, 6025–6041. https://doi.org/10.2147/JIR.S300989.

23.         Al-Lahham, S.H., Peppelenbosch, M.P., Roelofsen, H., Vonk, R.J., and Venema, K. (2010). Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms. Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids 1801, 1175–1183. https://doi.org/10.1016/J.BBALIP.2010.07.007.

24.         Radzinsky, V.E., Uspenskaya, Y., Shulman, L.P., and Kuznetsova, I. V. (2019). Succinate-Based Dietary Supplement for Menopausal Symptoms: A Pooled Analysis of Two Identical Randomized, Double-Blind, Placebo-Controlled Clinical Trials. Obstet Gynecol Int 2019, 1572196. https://doi.org/10.1155/2019/1572196.

25.         In, Y.W., Kim, J.J., Kim, H.J., and Oh, S.W. (2013). Antimicrobial Activities of Acetic Acid, Citric Acid and Lactic Acid against Shigella Species. J Food Saf 33, 79–85. https://doi.org/10.1111/JFS.12025.

The post The Postbiotics and Probiotics of YIXIY appeared first on YIXIY.

1. Start your day right: A healthy breakfast, featuring YIXIY with postbiotics, nourishes your gut, supporting a balanced microbiome from the first hours of your day.
2. Postbiotics from YIXIY help nourish your gut: They fuel colon cells, improve nutrient absorption, and strengthen the gut lining.
3. Gut health is like fertile soil: A healthy microbiome creates an environment where your gut thrives, while poor gut health can leave your body vulnerable.
4. Toxins can disrupt gut balance: Unhealthy habits like poor sleep, fast food, and alcohol can upset the microbiome, much like toxins harm fertile soil.
5. Postbiotics from YIXIY support detoxification: They help the gut, liver, and metabolism work together to detoxify the body.

How wonderful would it be if your healthy habits could be boosted while the impact of unhealthy choices would be mitigated? YIXIY brings postbiotics to the rescue!

In today’s fast-paced world, we’re constantly searching for quick fixes and instant results, especially when it comes to our health. We want the fastest, easiest solutions. But sometimes, true health benefits come from consistent, long-term care. In this blog, we’ll explore five reasons why incorporating pro- and postbiotics into your daily routine may be more effective for long-term health and well-being than relying on temporary fixes.

Your gut as fertile soil

Just like healthy soil supports plants to thrive, a healthy microbiome cultivates the perfect environment for your gut to flourish. We all know our intestines digest food to provide energy and nutrients to the rest of our body. But did you know that postbiotics help nourish our intestines? Postbiotics, like butyrate, fuel up to 70% of the energy for our colon cells¹. Not only do they provide energy, but postbiotics also enrich the gut’s ecosystem, promoting gut motility^2,3 and helping food pass through more efficiently. Just as healthy soil allows plants to absorb nutrients better, a balanced microbiome ensures more effective nutrient uptake, while keeping harmful pathogens out by strengthening the gut lining. In contrast, poor gut health—like poor soil to plants —can leave your body in a vulnerable, suboptimal state. Additionally, postbiotics also have an anti-inflammatory effect^4,5, further supporting gut health. A healthy gut truly is well-nourished soil cultivating your overall well-being!

Toxin-threats to the fertile soil

While we may have the best intentions for maintaining a healthy lifestyle, temptations like fast food or alcohol can easily lead us astray. Additionally, poor sleep, insufficient exercise, or air pollution can pose other daily challenges to our microbiome^4,6–9. These choices can disrupt the balance of gut bacteria, just like toxins harming fertile soil. Did you know that postbiotics support your body’s detoxification processes by promoting gut health, enhancing liver function, and boosting metabolism?  In this way, a healthy gut acts like well-maintained soil, mitigating the negative effects of unhealthy choices and harmful environmental influences.

Plant the seeds!

After hours of sleep, your body’s metabolism naturally slows down, and a healthy breakfast is just what you need to wake it up. Eating a balanced breakfast jumpstarts your metabolism, setting the tone for the rest of the day. Including a shot of YIXIY with 19 fermented herbs and postbiotics is an effortless way to nourish your gut and kickstart your day.

In summary, a healthy gut is like fertile soil, and postbiotics can act like soil improvers that help it thrive. They limit the impact of unhealthy choices while enhancing the benefits of healthy ones. Our gut is doing its best to support us—are you returning the favor?

References

1.            Pryde, S.E., Duncan, S.H., Hold, G.L., Stewart, C.S., and Flint, H.J. (2002). The microbiology of butyrate formation in the human colon. FEMS Microbiol Lett 217, 133–139. https://doi.org/10.1111/J.1574-6968.2002.TB11467.X.

2.            Cherbut, C., Aubé, A.C., Blottière, H.M., and Galmiche, J.P. (1997). Effects of Short-Chain Fatty Acids on Gastrointestinal Motility. Scand J Gastroenterol 32, 58–61. https://doi.org/10.1080/00365521.1997.11720720.

3.            Margolis, K.G., Cryan, J.F., and Mayer, E.A. (2021). The Microbiota-Gut-Brain Axis: From Motility to Mood. Gastroenterology 160, 1486–1501. https://doi.org/10.1053/J.GASTRO.2020.10.066.

4.            Siddiqui, M.T., and Cresci, G.A.M. (2021). The Immunomodulatory Functions of Butyrate. J Inflamm Res 14, 6025–6041. https://doi.org/10.2147/JIR.S300989.

5.            Meijer, K., De Vos, P., and Priebe, M.G. (2010). Butyrate and other short-chain fatty acids as modulators of immunity: What relevance for health? Curr Opin Clin Nutr Metab Care 13, 715–721. https://doi.org/10.1097/MCO.0B013E32833EEBE5.

6.            Benedict, C., Vogel, H., Jonas, W., Woting, A., Blaut, M., Schürmann, A., and Cedernaes, J. (2016). Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals. Mol Metab 5, 1175–1186. https://doi.org/10.1016/J.MOLMET.2016.10.003.

7.            Vieceli, T., Tejada, S., Martinez-Reviejo, R., Pumarola, T., Schrenzel, J., Waterer, G.W., and Rello, J. (2023). Impact of air pollution on respiratory microbiome: A narrative review. Intensive Crit Care Nurs 74, 103336. https://doi.org/10.1016/J.ICCN.2022.103336.

8.            Mousavi, S.E., Delgado-Saborit, J.M., Adivi, A., Pauwels, S., and Godderis, L. (2022). Air pollution and endocrine disruptors induce human microbiome imbalances: A systematic review of recent evidence and possible biological mechanisms. Science of The Total Environment 816, 151654. https://doi.org/10.1016/J.SCITOTENV.2021.151654.

9.            Divella, R., De Palma, G., Tufaro, A., Pelagio, G., Gadaleta-Caldarola, G., Bringiotti, R., and Paradiso, A. (2021). Diet, Probiotics and Physical Activity: The Right Allies for a Healthy Microbiota. Anticancer Res 41, 2759–2772. https://doi.org/10.21873/ANTICANRES.15057.

The post Your gut as fertile soil with postbiotics  “YIXIY as soil” appeared first on YIXIY.

1. Long-term benefits: Research shows that regular use enhances mental flexibility, reduces stress, and supports overall gut health across all ages.
2. Daily challenges for the microbiome: Diet, poor sleep, and pollution disrupt gut health, but pro- and postbiotics help restore balance.
3. Habit formation: It takes 66 days to form a habit. Incorporating pro- and postbiotics into your routine becomes effortless over time.
4. The compound effect: Small, consistent actions like daily probiotic use can lead to significant health improvements in the long term.
5. Prevention over cure: Pro- and postbiotics strengthen immunity, reduce inflammation, and help prevent illness.

“Pro- and postbiotics are gaining attention as a natural way to support gut health and overall wellness. But why are they so effective? And how can consistent use make a difference in your health journey? Let’s dive deeper into the science and practical benefits of these powerful allies for your microbiome.”

In today’s fast-paced world, we’re constantly searching for quick fixes and instant results, especially when it comes to our health. We want the fastest, easiest solutions. But sometimes, true health benefits come from consistent, long-term care. In this blog, we’ll explore five reasons why incorporating pro- and postbiotics into your daily routine may be more effective for long-term health and well-being than relying on temporary fixes.

Daily challenges for our microbiome

Did you know that your microbiome faces daily challenges? From unhealthy food choices like processed snacks¹ and sugary drinks to alcohol consumption⁵ and air pollution^2,6, our gut microbiome is constantly impacted. And let’s not forget how sleep deprivation¹⁰ and lack of physical activity¹² can disrupt the balance of good bacteria in our gut.

While no single habit can undo these challenges, consistently incorporating healthy practices—like taking probiotics—can provide valuable support. Daily care helps maintain balance and supports overall health, even when life’s stressors take their toll. It’s all about making small, sustainable choices that add up over time and keep your gut in good shape.

Habit formation

Did you know it takes on average 66 days to form a new habit?³ Habits help make life easier by turning actions into automatic behaviors, saving your brain’s energy for more complex tasks. With practice, your brain becomes more efficient, and the more you repeat a behavior, the less mental effort it takes. This is why habits are so powerful—they help you stay consistent and reduce the mental energy needed for everyday tasks, leaving you free to focus on bigger challenges.

When it comes to supporting your health, making daily habits like taking probiotics or postbiotics part of your routine can offer significant benefits for both physical and mental well-being. The best part? Once these habits are established, they require less willpower to maintain and become second nature, allowing you to stick with them without constant effort or motivation.

The compound effect of daily habits: small actions, big results

Have you ever thought about how small actions in your everyday life add up over time? At first, making a choice that’s just 1 percent better or worse may not seem to make much of a difference. However, over time, these tiny improvements or setbacks compound, and soon enough, a big gap forms between those who make slightly better choices each day and those who don’t.

If you improve by just 1 percent every day for a year, you’ll end up thirty-seven times better by the end of it (Figure 1, source: JamesClear.com).). This is why small choices may seem insignificant in the moment, but in the long run, they can lead to substantial results. So, whether it’s taking probiotics daily or making other healthy choices, small, consistent actions can lead to big, lasting changes over time.

Prevention

Do you know what’s better than recovering fast once you’re ill? Trying to prevent getting sick in the first place! Both pro- and postbiotics have been shown to play a significant role in supporting the immune system by promoting a healthy gut microbiome ^4,7–9, which is crucial for immune function. By maintaining a balanced microbiome, these beneficial microbes can help regulate immune responses, reduce inflammation, and improve the body’s ability to fight off infections. This means that incorporating pro- and postbiotics into your daily routine may be a proactive way to bolster your body’s natural defenses and keep illness at bay.

Long-term probiotic use

While research on the long-term use of postbiotics is still limited, studies on probiotics have typically lasted between 10 days and 12 weeks¹¹. Most of these studies have focused on older adults^11,13. For example, a study with healthy adults over 65, who took Bifidobacterium bifidum and Bifidobacterium longum for 12 weeks, found that probiotics helped improve mental flexibility, reduce stress, and change the gut bacteria in ways that were linked to better brain function¹³. Another study with healthy young adults showed that taking Lactobacillus casei for three weeks improved immune health, reduced oxidative stress, and helped balance gut bacteria¹⁴. These findings suggest that long-term probiotic use can have a positive impact on both mental and physical health in both young and older adults.

In conclusion, incorporating pro- and postbiotics into your daily routine offers a range of benefits that can support your health over time. From helping to navigate daily challenges to promoting healthy habits, the consistent use of probiotics can improve both mental and physical well-being. While no single habit is a cure-all, the compound effect of small, daily actions can contribute to long-term health improvements.

So, instead of relying on quick fixes, consider making probiotics a part of your everyday routine for a more sustainable approach to wellness. Every small step can help support your body’s natural balance, one day at a time. What’s one thing you can do today to build 1% healthier habits than yesterday?

References

1.           Zinöcker, M.K., and Lindseth, I.A. (2018). The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease. Nutrients 2018, Vol. 10, Page 365 10, 365. https://doi.org/10.3390/NU10030365.

2.            Vieceli, T., Tejada, S., Martinez-Reviejo, R., Pumarola, T., Schrenzel, J., Waterer, G.W., and Rello, J. (2023). Impact of air pollution on respiratory microbiome: A narrative review. Intensive Crit Care Nurs 74, 103336. https://doi.org/10.1016/J.ICCN.2022.103336.

3.            Lally, P., Van Jaarsveld, C.H.M., Potts, H.W.W., and Wardle, J. (2010). How are habits formed: Modelling habit formation in the real world. Eur J Soc Psychol 40, 998–1009. https://doi.org/10.1002/EJSP.674.

4.            Ruff, W.E., Greiling, T.M., and Kriegel, M.A. (2020). Host–microbiota interactions in immune-mediated diseases. Nature Reviews Microbiology 2020 18:9 18, 521–538. https://doi.org/10.1038/s41579-020-0367-2.

5.            Engen, P.A., Green, S.J., Voigt, R.M., Forsyth, C.B., and Keshavarzian, A. (2015). The Gastrointestinal Microbiome: Alcohol Effects on the Composition of Intestinal Microbiota. Alcohol Res 37, 223.

6.            Mousavi, S.E., Delgado-Saborit, J.M., Adivi, A., Pauwels, S., and Godderis, L. (2022). Air pollution and endocrine disruptors induce human microbiome imbalances: A systematic review of recent evidence and possible biological mechanisms. Science of The Total Environment 816, 151654. https://doi.org/10.1016/J.SCITOTENV.2021.151654.

7.            Perdigón, G., Maldonado Galdeano, C., Valdez, J.C., and Medici, M. (2003). Interaction of lactic acid bacteria with the gut immune system. European Journal of Clinical Nutrition 2002 56:4 56, S21–S26. https://doi.org/10.1038/sj.ejcn.1601658.

8.            Arunachalam, K., Gill, H.S., and Chandra, R.K. (2000). Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019). European Journal of Clinical Nutrition 2000 54:3 54, 263–267. https://doi.org/10.1038/sj.ejcn.1600938.

9.            Tsai, Y.T., Cheng, P.C., and Pan, T.M. (2012). The immunomodulatory effects of lactic acid bacteria for improving immune functions and benefits. Appl Microbiol Biotechnol 96, 853–862. https://doi.org/10.1007/S00253-012-4407-3/FIGURES/3.

10.         Benedict, C., Vogel, H., Jonas, W., Woting, A., Blaut, M., Schürmann, A., and Cedernaes, J. (2016). Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals. Mol Metab 5, 1175–1186. https://doi.org/10.1016/J.MOLMET.2016.10.003.

11.         Gao, R., Zhang, X., Huang, L., Shen, R., and Qin, H. (2019). Gut Microbiota Alteration After Long-Term Consumption of Probiotics in the Elderly. Probiotics Antimicrob Proteins 11, 655–666. https://doi.org/10.1007/S12602-018-9403-1/FIGURES/7.

12.         Divella, R., De Palma, G., Tufaro, A., Pelagio, G., Gadaleta-Caldarola, G., Bringiotti, R., and Paradiso, A. (2021). Diet, Probiotics and Physical Activity: The Right Allies for a Healthy Microbiota. Anticancer Res 41, 2759–2772. https://doi.org/10.21873/ANTICANRES.15057.

13.         Kim, C.S., Cha, L., Sim, M., Jung, S., Chun, W.Y., Baik, H.W., and Shin, D.M. (2021). Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial. The Journals of Gerontology: Series A 76, 32–40. https://doi.org/10.1093/GERONA/GLAA090.

14.         Mei, L.H., Zheng, W.X., Zhao, Z.T., Meng, N., Zhang, Q.R., Zhu, W.J., Li, R.D., Liang, X.L., and Li, Q.Y. (2021). A Pilot Study of the Effect of Lactobacillus casei Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers. Nutrients 2021, Vol. 13, Page 3891 13, 3891. https://doi.org/10.3390/NU13113891.

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1. Postbiotics strengthen the gut barrier and reduce inflammation, supporting immune health and peak performance.
2. Postbiotics like butyrate fuel intestinal cells, providing essential energy and enhancing gut motility for efficient digestion.

We all know our intestines digest food to provide energy, vitamins, and nutrients to the rest of our body. But did you know that postbiotics help fuel your intestines?

Postbiotics, like butyrate, aren’t just “nice-to-haves” for your gut—they’re key to your body’s energy engine. Did you know that butyrate provides up to 70% of the energy required for your colon cells? (Pryde et al., 2002) This source of energy plays an important role in keeping your body running efficiently.

But it doesn’t stop there. Postbiotics also support gut motility (Cherbut et al., 1997; Martin-Gallausiaux et al., 2021), ensuring that your digestive process is as efficient as your workflow—getting nutrients absorbed quickly while helping waste move through smoothly. And because postbiotics enhance the gut barrier function (Martin-Gallausiaux et al., 2021; Van Hook, 2015), they not only help your body absorb the essentials, but also keep harmful invaders at bay. By supporting these vital processes, postbiotics help your body function at its best every day.

For individuals committed to high performance, postbiotics can also modulate inflammation (Meijer et al., 2010; Siddiqui & Cresci, 2021) —reducing gut stress. A healthy gut serves as a critical foundation for a well-functioning immune system, allowing you to stay focused on your performance. A healthy gut isn’t just about digestion; it’s about fueling peak performance in all areas of life. Take care of your gut, and your gut will take care of you by helping your gut you stay ahead of the curve, day in and day out.

References

Cherbut, C., Aubé, A. C., Blottière, H. M., & Galmiche, J. P. (1997). Effects of Short-Chain Fatty Acids on Gastrointestinal Motility. Scandinavian Journal of Gastroenterology, 32(222), 58–61. https://doi.org/10.1080/00365521.1997.11720720

Martin-Gallausiaux, C., Marinelli, L., Blottière, H. M., Larraufie, P., & Lapaque, N. (2021). SCFA: mechanisms and functional importance in the gut. Proceedings of the Nutrition Society, 80(1), 37–49. https://doi.org/10.1017/S0029665120006916

Meijer, K., De Vos, P., & Priebe, M. G. (2010). Butyrate and other short-chain fatty acids as modulators of immunity: What relevance for health? Current Opinion in Clinical Nutrition and Metabolic Care, 13(6), 715–721. https://doi.org/10.1097/MCO.0B013E32833EEBE5

Pryde, S. E., Duncan, S. H., Hold, G. L., Stewart, C. S., & Flint, H. J. (2002). The microbiology of butyrate formation in the human colon. FEMS Microbiology Letters, 217(2), 133–139. https://doi.org/10.1111/J.1574-6968.2002.TB11467.X

Siddiqui, M. T., & Cresci, G. A. M. (2021). The Immunomodulatory Functions of Butyrate. Journal of Inflammation Research, 14, 6025–6041. https://doi.org/10.2147/JIR.S300989

Van Hook, A. M. (2015). Butyrate benefits the intestinal barrier. Science Signaling, 8(378). https://doi.org/10.1126/SCISIGNAL.AAC6198

The post Fuel your performance with postbiotics appeared first on YIXIY.

1. Feed the Good: Probiotics from YIXIY, such as Lactobacillus acidophilus and Bifidobacterium lactis, strengthen digestion, support nutrient absorption, and diversify gut bacteria.
2. Limit the Bad: Postbiotics from YIXIY, like butyric acid, reduce inflammation, fortify the gut barrier, and protect against toxins from poor diets and environmental stressors.

Together, probiotics and postbiotics ensure a resilient microbiome that promotes long-term health and well-being.

Did you know that your gut microbiome is home to trillions of bacteria which play a critical role in your overall health? In this blog we will discuss how probiotics and postbiotics can stimulate gut health and how a healthy microbiome can protect us by limiting the harmful effects of both poor diet and environmental toxins.

Feed the Good: How probiotics support your gut health

A balanced microbiome is essential for proper digestion, immune function, and protecting the body from harmful pathogens^1,3,5. One way to support and strengthen your microbiome is by incorporating probiotics into your diet. Probiotics are live beneficial bacteria that help diversify gut bacteria, promoting better digestive health and disease protection.

Certain strains, such as Lactobacillus acidophilus, Bifidobacterium lactis, Lactobacillus rhamnosus, and Lactobacillus casei, offer powerful digestive benefits^2,4. They assist in breaking down food, absorbing nutrients, and keeping digestion regular^6–8. A healthy, well-balanced microbiome supports efficient nutrient absorption and regular bowel movements, helping you feel energized and maintain overall health¹⁰.

Limiting the Bad: Protecting your microbiome from toxins

While probiotics are vital for a healthy microbiome, external factors, such as an unhealthy diet and environmental toxins, can disrupt this balance^11–13. Diets high in processed foods, artificial sweeteners, and excess sugar can harm your microbiome^14,16 by promoting harmful bacteria. This imbalance may lead to digestive issues, weight gain, and long-term conditions like heart disease and diabetes^17–20. Additionally, sugar and additives can trigger inflammation in the gut, weakening the gut lining and allowing leakage of toxins into the bloodstream, potentially causing widespread inflammation throughout the body. A compromised microbiome can also impair your immune system²¹, making it harder to fight infections²².

This is where postbiotics come in as a game-changer. While probiotics help introduce beneficial bacteria to your gut, postbiotics are the bioactive compounds produced by these bacteria that deliver direct, immediate health benefits. One of the most powerful types of postbiotics are short-chain fatty acids (SCFAs) like butyric acid, propionic acid, succinic acid, lactic acid, and acetic acid. These postbiotics have shown to reduce inflammation^23,24, enhance gut motility^26,28  and protect the gut barrier²⁷. Hereby providing rapid relief and protection against the harmful effects of poor diet, toxins, and environmental stressors.

What sets postbiotics apart is their ability to provide immediate benefits that go beyond what probiotics alone can offer. Unlike probiotics that take time to colonize and start working, postbiotics act right away, offering direct protection for the gut. By fortifying the gut barrier and reducing gut permeability, postbiotics make it harder for harmful substances to leak into the bloodstream, reducing chances of widespread inflammation and supporting overall immune health. Additionally, postbiotics can also regulate immune function²⁵, strengthening the body’s resilience to external stressors. This makes postbiotics a powerful, protective tool that complements the benefits of probiotics and ensures a gut that is not only well-populated with good bacteria but also equipped to thrive in a challenging environment.

Additionally, environmental toxins, such as those found in air pollution, can reduce the diversity of beneficial bacteria in your microbiome, allowing harmful bacteria to thrive ¹¹. Taking a probiotic with multiple strains of beneficial bacteria can help restore and diversify your microbiome¹⁵, with the postbiotics produced by these probiotics acting as your gut’s first line of defense. They ensure your microbiome isn’t just replenished, but actively protected from the harmful effects of toxins and stressors.

Feed and protect your gut for better health

A balanced microbiome is essential for optimal health, playing a key role in digestion, immune function, and overall well-being. By incorporating probiotics and postbiotics into your diet, you can nourish your gut with beneficial bacteria that improve digestion, strengthen the gut barrier, and modulate inflammation. This not only supports a healthier digestive system but also helps limit harmful effects from an unhealthy diet, pollution, and other external stressors.

Feed the good bacteria in your gut, and in turn, they’ll continue to feed and protect your health. By supporting your microbiome with a combination of the right nutrients, probiotics and postbiotics you’re investing in a healthier, more resilient body. What is your next step to do good for your gut?

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Digestive Dynamo: Your gut is home to about 10 times more microbes than human cells. Keeping these tiny helpers happy supports smooth and efficient digestion. 

1. Immune Powerhouse: Did you know 70% of your immune system is located in your gut? A healthy gut can mean a stronger defense against illnesses. 

1. Vitamin Factory: Your gut bacteria help produce essential vitamins like B12 and vitamin K. It’s like having a personal vitamin factory inside you! 

1. Gut Feelings: 95% of serotonin is produced in the intestines. Through the gut-brain axis—the bidirectional communication system between the gut and the brain—serotonin produced in the gut can influence brain activity, ultimately impacting mood and mental well-being. 

1. Energy Boost: A well-balanced gut microbiome helps break down food more efficiently, leading to better nutrient absorption. Proper nutrient absorption is essential for your body to make use of the nutrients present in your food. 

What is your next step in taking care of your gut health? 

The post Why is gut health important?  appeared first on YIXIY.

Imagine this: while probiotics are the live microorganisms themselves (think lactic acid bacteria — read more about them on our blog), postbiotics are the powerful substances these microorganisms leave behind after they’ve done their job. 

Think of it as a natural cycle: just like trees transform the carbon dioxide we exhale into oxygen, postbiotics ensure that your body gets the benefits of this extraordinary process. Far from being “waste,” these are valuable byproducts that can give your health a serious boost!

Microbiome, microbes, micro-what?

The microbiome consists of all the microbes living in and on our bodies. Microbes are tiny organisms, too small to be seen without a microscope. Altogether, we carry about ten times more microbial cells than human cells, which weigh approximately 1.5 kg—about as much as our brain! 

Each person has a unique combination of microbes, similar to the composition of a fingerprint (source: Harvard T.H. Chan School of Public Health). Bacteria and fungi are the most prevalent types of microbes in our bodies. A common group of bacteria is Lactobacilli or lactic acid bacteria (and for the biology enthusiasts out there, these bacteria belong to the phylum Firmicutes). Lactobacilli can thrive in challenging environments, such as low oxygen or high acidity. In our bodies, they are predominantly found in the intestines but are also present in smaller amounts on our skin, as well as in the respiratory and urinary tracts. 

How do lactic acid bacteria contribute to our health? 

 Lactic acid bacteria aid digestion by breaking down complex carbohydrates, fibers, sugars, and proteins. These bacteria can even produce important vitamins, such as vitamin K and B vitamins. Additionally, lactic acid bacteria support gut health by helping Page 2 of 2 

to maintain the integrity of the intestinal walls (epithelial barrier), which is crucial for a healthy digestive system. 

Besides their digestive benefits, lactic acid bacteria play a vital role in our immune system. They help train our immune system, modulate inflammatory responses, and protect our health by competing with harmful pathogens for space and resources, thereby reducing the likelihood of infections. 

Overall, lactic acid bacteria significantly contribute to our well-being by supporting digestion, producing vitamins, and enhancing immune function. So, rather than viewing them as villains, let’s appreciate and nurture our health-promoting bacteria! 

What is your next step in taking care of your microbiome? 

The post Why are lactic acid bacteria important?  appeared first on YIXIY.

Key Highlights:

1. Energy Provision: Postbiotics like butyric acid provide energy to intestinal cells and support efficient gut function.
2. Anti-Inflammatory Effects: They help reduce inflammation and contribute to a healthy immune response.
3. Gut Barrier Strengthening: Postbiotics enhance the integrity of the intestinal barrier, which is essential for keeping harmful substances out.
4. Production of Neurotransmitters: Certain postbiotics support the production of compounds like serotonin and GABA, contributing to emotional well-being and stress reduction.

These combined functions make postbiotics essential for resilient gut health, optimizing digestion, and supporting energy, immunity, and mental balance.

Why choose postbiotics? 

In this document postbiotics are listed that, in principle, could be generated by bacterial strains in YIXIY. The following bacterial strains have been considered:
Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidobacterium lactis, Lactobacillus casei, Lactobacillus salivarius, Lactococcus lactis and Streptococcus thermophilus.

For each postbiotic, the bacterial strains are listed which could potentially generate this postbiotic and are present in YIXIY (i.e. the bacterial strains are present in YIXIY, the amount of postbiotic would need to be quantified at e.g. a lab to determine its presence/quantity. Both the presence and quantity are required to determine whether there could potentially be any health effects).

NB I: The involvement of the bacterial strains has not been verified in all cases by scientific articles. The reference has been mentioned in case a specific scientific article was consulted.

NB: In general in this research, it is relevant to be careful with in-vivo (in a living organism) versus in vitro (e.g. in a petri-dish or medium) applications. E.g. if a bacterium shows to lower cholesterol in a petri-dish, it does not automatically mean that this will also happen inside the human body. The petri-dish is a very isolated environment, in the complex human body there may be other processes that inhibit this process e.g. hampering this decrease of cholesterol.

Short-Chain Fatty Acids (SCFAs)

Short-Chain Fatty acids (SCFAs) are produced by gut microbiota from indigestible food components (such as fibers and certain sugar derivations) (Teame et al., 2020).

• Lactic Acid
  Function: pH regulation (low pH), inhibition of pathogens, mucosal barrier support, nutrient absorption & modulation of immune response)
  • Bifidobacterium longum
  • Lactobacillus acidophilus
  • Lactobacillus rhamnosus
  • Bifidobacterium lactis
  • Lactobacillus casei
  • Lactobacillus salivarius
  • Lactococcus lactis

Streptococcus thermophilus

• Acetate
  Function: Energy source for colonocytes (cells lining the colon), pH regulation (low pH), gut motility, anti-inflammatory
  • Bifidobacterium longum
  • Lactobacillus acidophilus
  • Lactobacillus rhamnosus
  • Bifidobacterium lactis
  • Lactobacillus casei
  • Lactobacillus salivarius
  • Lactococcus lactis

Streptococcus thermophilus

• Propionate
  Regulation of blood sugar levels, cholesterol metabolism, anti-inflammatory effects, appetite regulation, gut barrier function
  • Lactobacillus rhamnosus (LeBlanc et al., 2017) (article shows propionate production by this strain)

NB: Butyrate may also be an available postbiotic, but in principle one would expect to find this compound at (even) lower quantities.

Conjugated linoleic acid (CLA)

Function: Described for anticarcinogenic effects (anti-cancer) in animal studies (Belury, 2002; Kim & Park, 2003)

• Lactobacillus acidophilus
  • Lactobacillus rhamnosus

Neurotransmitters

Gut bacteria can mediate the availability of various neurotransmitters, either by directly producing these or modulating their availability (Barandouzi et al., 2022; Dicks, 2022; Oleskin et al., 2016; Strandwitz, 2018).

• GABA
  Function: GABA is the primary inhibitory neurotransmitter in the brain. It can reduce anxiety and promote relaxation
  • Lactobacillus acidophilus
  • Lactobacillus rhamnosus
• Histamine
  Function: Histamine is involved in local immune responses and mediates allergic reactions
  • Lactobacillus acidophilus
  • Lactobacillus casei
  • Lactobacillus rhamnosus
  • Lactococcus lactis (Özoğul et al., 2012) – in vitro
  • Streptococcus thermophilus (Özoğul et al., 2012) – in vitro
• Serotonin
  Function: Serotonin aids regulation of mood, anxiety and overall emotional well-being. Additionally, it is involved in controlling gastrointestinal motility
  • Lactococcus lactis (Özoğul et al., 2012) – in vitro
  • Streptococcus thermophilus (Özoğul et al., 2012) – in vitro
• Dopamine
  Function: Essential for reward, motivation and motor control
  • Lactococcus lactis (Özoğul et al., 2012) – in vitro
  • Streptococcus thermophilus (Özoğul et al., 2012) – in vitro

NB: Potentially, there are microbacteria that are involved in the generation of neurotransmitters. This would require some follow-up literature search.

Bacteriocins

Function: Bacteriocins are proteins produced by bacteria that kill or inhibit the growth of other bacteria. They act like a defense mechanism, allowing the producing bacteria to compete with or eliminate other (pathogenic) microbes in their environment (Riley & Wertz, 2002).

• Acidocin
  • Lactobacillus acidophilus
• Bifidocin B
  • Bifidobacterium longum
• Caseicins
• Lactobacillus casei
• Salivaricin
  • Lactobacillus salivarius
• Nisin
  • Lactococcus lactis
• Lacticin 3147
  • Lactococcus lactis
• Thermophilin
  • Streptococcus thermophilus

Vitamins

• Folate (Vitamin B9)
  Function: A.o. involved in red blood cell formation
  • Bifidobacterium longum
  • Lactobacillus casei
  • Lactobacillus rhamnosus (LeBlanc et al., 2017)
• Lactococcus lactis (Gu & Li, 2016)
  Menaquinone (Vitamin K2)
  Function: Contributes to strong bones and adequate blood clotting
  • Lactococcus lactis (Gu & Li, 2016)
  • Lactobacillus salivarius
  • Lactobacillus casei
• Riboflavin (Vitamin B2)
  • Lactobacillus rhamnosus (LeBlanc et al., 2017)
• NB: Potentially, there are more B vitamins that lactobacilli can generate. This would require some follow-up literature search.

Cell wall components

• Studies confirmed that cell surface components of Lactobacilli are considered as important communicators (effector molecules), as this part of the microbial cell is the first to interact with host cells. Even after bacterial cells are dead, their cell wall components and surface-associated proteins can retain some health functions, particularly related to immune modulation and gut health.
• Peptidoglycan (Teame et al., 2020)
• Teichoic acid (Teame et al., 2020)
• Cell-wall polysaccharides (exopolysaccharides (EPS)) (Teame et al., 2020)
• Cell surface-associated proteins (LPXTG proteins,S-layer proteins, pili proteins, moonlight proteins) (Teame et al., 2020)

NB: In the article of Teame et al., these cell wall components are categorized as para-biotics. However, according to the Nature commission’s definition these may also fall under the postbiotics. “The panel defined a postbiotic as a “preparation of inanimate microorganisms and/or their components that confers a health benefit on the host. Effective postbiotics must contain inactivated microbial cells or cell components, with or without metabolites, that contribute to observed health benefits.”  (Salminen et al., 2021).

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